Discover the Project
Fungal metabolites as potential antiviral in canine and feline coronaviruses infection: investigation of their activity and mechanism of action
NATURAL COMPOUNDS DISCOVERY
Screening fungal strains (Talaromyces and Diplodia) to isolate and chemically characterize potent secondary metabolites…
IN VITRO AND SILICO ANTIVIRAL SCREENING
In vitro and in silico evaluation of selected metabolites against Canine (CCoV) and Feline (FCoV) Coronaviruses.
MECHANISM OF ACTION
Investigating the therapeutic role of metabolites by mapping their interaction with host receptors (AhR/FPRs) and metal ions.
ONE HEALTH APPROACH
Developing broad-spectrum antiviral compounds relevant for both animal and humans by global health strategies.
Meet the Team
Our project is driven by a specialized collaboration between two Research Units (RU1 – UNINA and RU2 – UNIBA), led by Prof. Filomena Fiorito and Prof. Annamaria Pratelli.
The team combines leading expertise in Virology, Molecular Biology, and Natural Chemistry to deliver a comprehensive, One Health approach to antiviral drug discovery.
Workshop
The PRIN2022 PNRR project hosted two workshops exploring the potential of fungal metabolites as natural antivirals against animal coronaviruses. The sessions brought together leading researchers from UNINA, UNIBA, and UNICAMPANIA to discuss the latest findings on secondary metabolites, including funicones and sphaeropsidines, their antiviral activity, and mechanisms of action involving host receptors such as AhR and FPRs.
The workshops featured presentations on in vitro studies, in silico analyses, and innovative approaches to antiviral research, highlighting a One Health perspective.
For full details on the workshops, speakers, and program, read the full article here.
